Product Details
Place of Origin: SiChuan,China
Brand Name: YHF
Certification: ISO/HACCP/KOSHER/GMPs/FDA
Model Number: 520-27-4
Payment & Shipping Terms
Minimum Order Quantity: Minimum standard package， for the detail, please refer to "regular package"
Price: Negotiate
Packaging Details: 25kg/drum
Delivery Time: 30 work days after receiving firm order.
Product Name: |
Diosmin |
Raw Material: |
Hesperidine |
CAS: |
520-27-4 |
Formula: |
C28H32O15 |
MOL WT: |
609 |
Test Method: |
HPLC/UV |
Form: |
Powder |
Shelf LIfe: |
2 Years |
Product Name: |
Diosmin |
Raw Material: |
Hesperidine |
CAS: |
520-27-4 |
Formula: |
C28H32O15 |
MOL WT: |
609 |
Test Method: |
HPLC/UV |
Form: |
Powder |
Shelf LIfe: |
2 Years |
Hot Sale Diosmin Powder From Immature Bitter Orange CAS 520-27-4 Diosmin
Product Information
Product Name: Diosmin
Raw Material: Hesperidine
CAS: 520-27-4
MF: C28H32O15
Supplier Name: Hebei Disha Import and Export Trade Co. LTD
Shelf Life: 24 Months
Package: 1kg/foil bag(net weight 1kg, gross weight 1.2kg), 25kg/fiber drum(net weight 25kg, gross weight 28kg)According to customer needs
Storage: Stored in a cool and dry well closed container and in ventilated area, kept away from moisture and strong light or high temperature.
Diosmin differs molecularly from hesperidin by the presence of a double bond between two carbon atoms in diosmin's central carbon ring. Diosmin can be manufactured by extracting hesperidin from citrus rinds, followed by conversion of hesperidin to diosmin. Diosmin has been used for more than 30 years as a phlebotonic and vascular-protecting agent, and has recently begun to be investigated for other therapeutic purposes, including cancer, premenstrual syndrome, colitis, and diabetes.
Specification
| DETERMINATIONS | SPECIFICATIONS |
| Appearance | Grayish-yellow or light yellow hygroscopic powder. |
| Solubility | Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in ethanol(96 per cent). It dissolves in dilute solutions of alkali hydroxides. |
|
Identification (2.2.24 & 2.2.29Ph Eur.1611) |
A. Infrared absorption spectrophotometry Camparison:diosmin CRS |
| B. The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (a) | |
| Iodine(2.2.36&2.5.10Ph Eur.1611) | ≤0.1% |
|
Related substances (HPLC) (2.2.29Ph Eur.1611) |
Impurity A (Acetoisovanillone) ≤0.5% |
| Impurity B (Hesperidin) ≤ 4.0% | |
| Impurity C ( Isorhoifolin) ≤3.0% | |
| Impurity D (6-Iododiosmin) ≤0.6% | |
| Impurity E (Linarin) ≤3.0% | |
| Impurity F (Diosmetin) ≤2.0% | |
| Any unspecified impurity ≤0.4% | |
| Total of impurities ≤8.5% | |
|
Heavy metals (2.4.8 Method C Ph Eur.1611) |
≤20ppm |
| Hg (AAS) | ≤0.10ppm |
| Water (2.5.12Ph Eur.1611) | ≤6.0% |
| Sulphated ash (2.4.14Ph Eur.1611) | ≤0.2% |
|
Assay on anhydrous basis (2.2.29Ph Eur.1611) |
90.0%~102.0% (on anhydrous basis) |
| Pyridine (2.4.24Ph Eur.1611) | ≤200ppm |
|
Particle size (by laser granulometry) |
80%<2 micron |
|
Microbiological test (CP2010) |
Total bacteria count :≤1000cfu/g |
| Moulds and yeasts :≤100cfu/g | |
| Salmonella: Negative | |
| E.Coli :Negative |
Remarks: In a word, we can produce as per the client`s specific rquirements like particle size,color,solubility, signal heavy metal under Eu rules No629/2008, the other contaminants under EC1881/2006 and residual solvent under directive EC32/2009.
Function
1 Stimulate nervous system, promoting sexual function.
2 Antibacterial, anti-inflammatory, antitussive, anti-asthmatic and eliminating phlegm.
3 Tonifying kidney and boosting male virility, alleviating rheumatism, strengthening the muscles and bones.
4 Lowering blood pressure and blood sugar.
5 Anti-cancer and enhancing immunity
6 Restraining staphylococcus and delaying aging.
Application
Diosmin is mainly used in pharmaceutical feild for other therapeutic purposes, including cancer, premenstrual syndrome, colitis, and diabetes.
QUALITY ASSURANCE
Quality Assurance laboratory is well designed as per pharma standards having chemical and microbiological sections, apart from instrumentation room. All sections have latest testing instruments, which are handled by qualified and experience technical personnel assuring the quality of in put raw material and final products as per laid down specifications. In process control ( IPC ) tests are carried out at specified stage of processes to conform that quality standards are met .YHF Quality Assurance team monitors the quality of the products right from the raw materials procurement stage to the expiry date of the finished product, thus ensuring the customers get the finest products. In order to insure the quality, Our Team control raw material strictly. All the products should be record with all the procedure so that we can check each step easily.
The guide of purchase
1. Decide a purchase
Please confirm categories, quantity and total prices of products which you require with our sales department.
2. Remittance
Please check out the information of account with our sales representatives and make the payment to the appointed bank account.
3. Please fax to our company these documents after remittance.
a. Product names/quantities/and package size that you require.
b. Copy of remittance slip
c. Mailing address and the name of recipient
d. If you need the invoice, please fax the detailed information of your company.
4. Delivery
a. We will arrange the delivery in three work days after receiving the remittance slips if the products are in stock.
b. Without remittance slips, clients should inform our sales department the date of the payment.
c. Courier: EMS or others international couriers like Fedex.
